DNA-carrier proteins for targeted gene delivery
Identifieur interne : 002469 ( Main/Exploration ); précédent : 002468; suivant : 002470DNA-carrier proteins for targeted gene delivery
Auteurs : Christoph Uherek [Allemagne] ; Winfried Wels [Allemagne]Source :
- Advanced Drug Delivery Reviews [ 0169-409X ] ; 2000.
English descriptors
- Teeft :
- Acad, Adenoviral particles, Adenovirus, Adenovirus dodecahedron, Amino, Amino acids, Ammonium chloride, Bacterial protein toxins, Bacterial toxin, Bacterial toxins, Bacterial translocation domain, Binding activity, Binding domain, Biol, Capsid, Capsid proteins, Carrier protein, Carrier proteins, Catalytic activity, Catalytic domain, Cationic, Cell binding, Cell nucleus, Cell surface, Cell type, Cellular, Cellular barriers, Cellular membranes, Cellular uptake, Chimeric, Chimeric fusion protein, Chimeric fusion proteins, Chimeric molecule, Complex formation, Conformational change, Crystal structure, Cytosol, Deletion analysis, Different approach, Different functions, Different strategy, Diphtheria, Diphtheria toxin, Distinct activities, Dnacarrier protein, Domain, Drug deliv, Drug delivery reviews, Egfr, Elsevier science, Endocytosis, Endoplasmic reticulum, Endosomal, Endosomal compartment, Endosome, Endosome destabilization, Endosomes, Endosomolytic, Endosomolytic activity, Enzymatic domain, Epidermal growth factor, Epidermal growth factor receptor, Erbb2, Eukaryotic cells, Exotoxin, Functional domains, Fusion protein, Fusion proteins, Gain access, Gal4, Gal4 domain, Gal4 recognition motif, Gal4 recognition sequences, Gene, Gene delivery, Gene expression, Gene therapy, Gene transfer, Genetic immunotoxin, Growth factor, Growth factor receptors, Growth factors, Internalization, Intracellular delivery, Ligand, Lled bars, Localization, Localization signal, Luciferase, Luciferase activity, Luciferase reporter gene, Lung cancer cells, Lysine residues, Major capsid protein, Mammalian cells, Membrane interaction, Modular proteins, Molecular weight, Natl, Natural proteins, Nuclear envelope, Nuclear import, Nuclear proteins, Nuclear tropism, Nucleic acids, Passive diffusion, Peptide, Plasma membrane, Plasmid, Polyplex, Polyplexes, Pore, Pore formation, Proc, Protein, Pseudomonas, Pseudomonas aeruginosa, Pseudomonas exotoxin, Reagent, Receptor, Receptormediated endocytosis, Recombinant, Recombinant proteins, Retrograde transport, Retroviral vectors, Saccharomyces cerevisiae, Signal transduction, Simian virus, Single polypeptide chain, Small particles, Structural proteins, Target cells, Toxin, Transfect, Transfect cells, Transfection, Transfection experiments, Translocation, Translocation domain, Uherek, Unrelated control oligonucleotide, Viral, Viral capsid proteins, Viral particles, Wels.
Abstract
Abstract: The development of vectors for cell-specific gene delivery is a major goal of gene therapeutic strategies. Significant progress has been made in the construction of non-viral vectors that combine different functions required for gene transfer in an artificial complex. To some extent this can be achieved by complexing plasmid DNA with synthetic compounds such as lipids and polycations. Alternative approaches rely on the activities of natural or recombinant DNA-carrier proteins to achieve uptake and intracellular delivery of plasmid DNA. Nuclear proteins such as histones and members of the high mobility group protein family have been shown to condense DNA and transfect cultured cells. Some structural proteins of DNA viruses spontaneously assemble with plasmid DNA and form transfection-competent pseudocapsids. In addition, chimeric fusion proteins have been engineered that incorporate in a single polypeptide chain heterologous protein domains which facilitate binding to plasmid DNA, specific recognition of target cells, induction of receptor-mediated endocytosis, and DNA transport through intracellular compartments.
Url:
DOI: 10.1016/S0169-409X(00)00092-2
Affiliations:
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Significant progress has been made in the construction of non-viral vectors that combine different functions required for gene transfer in an artificial complex. To some extent this can be achieved by complexing plasmid DNA with synthetic compounds such as lipids and polycations. Alternative approaches rely on the activities of natural or recombinant DNA-carrier proteins to achieve uptake and intracellular delivery of plasmid DNA. Nuclear proteins such as histones and members of the high mobility group protein family have been shown to condense DNA and transfect cultured cells. Some structural proteins of DNA viruses spontaneously assemble with plasmid DNA and form transfection-competent pseudocapsids. In addition, chimeric fusion proteins have been engineered that incorporate in a single polypeptide chain heterologous protein domains which facilitate binding to plasmid DNA, specific recognition of target cells, induction of receptor-mediated endocytosis, and DNA transport through intracellular compartments.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Darmstadt</li><li>Hesse (Land)</li></region><settlement><li>Francfort-sur-le-Main</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Uherek, Christoph" sort="Uherek, Christoph" uniqKey="Uherek C" first="Christoph" last="Uherek">Christoph Uherek</name></region><name sortKey="Wels, Winfried" sort="Wels, Winfried" uniqKey="Wels W" first="Winfried" last="Wels">Winfried Wels</name><name sortKey="Wels, Winfried" sort="Wels, Winfried" uniqKey="Wels W" first="Winfried" last="Wels">Winfried Wels</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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